It is very important that opportunistic infections (HIV-associated infections which occur because the immune system has been weakened) are treated early and aggressively. If possible, tuberculosis should be well controlled before antiretroviral therapy is started. The use of prophylaxis with co-trimoxazole in children with immune suppression is important. INH prevention (prophylaxis) must be given to young children who have household contact with adults suffering from pulmonary tuberculosis.