- Pallor and bleeding
- Aching bones or joints, especially waking the child at night; backache
- Unexplained weight loss, fever or fatigue
- Persistent, unexplained lymphadenopathy
- Abdominal masses
- Lumps in the neck, testes or limbs
- Eye changes: white pupil, sudden squint or loss of vision, bulging eyeball
- Neurological symptoms or signs: headaches, early morning vomiting, unsteady gait, cranial palsies, change in behaviour
Children presenting with any of these warning (danger) symptoms or signs must be urgently referred for an expert opinion.