What are the side effects of anti-tuberculous drugs?

Unfortunately, all anti-TB drugs have side effects. In children these are fortunately not as severe as in adults. The organ most commonly affected by anti-TB drugs is the liver. Nausea and skin rashes may occur. The urine is often stained orange when rifampicin is given.

Table 2. Table 8.1: The usual 6-month treatment regimen for tuberculosis. R = Rifampicin; H = INH; Z = Pyrazinamide.
Pretreatment body weight 2 months
5 times per week
Initial phase: RHZ 60/30/150 mg
4 months
5 times per week
Continuation phase: RH 60/30 mg
3–4 kg ½ tablet ½ tablet
5–7 kg 1 tablet 1 tablet
8–9 kg 1 ½ tablets 1 ½ tablets
10–14 kg 2 tablets 2 tablets
15–19 kg 3 tablets 3 tablets
20–24 kg 4 tablets 4 tablets
25–29 kg 5 tablets 5 tablets
30–35 kg 6 tablets 6 tablets

All 3 antituberculous drugs (RMP, INH and PZA) may cause a drug induced hepatitis. INH may cause a peripheral neuropathy, but this is very uncommon in children.

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