Unfortunately, all anti-TB drugs have side effects. In children these are fortunately not as severe as in adults. The organ most commonly affected by anti-TB drugs is the liver. Nausea and skin rashes may occur. The urine is often stained orange when rifampicin is given.
| Pretreatment body weight | 2 months 5 times per week Initial phase: RHZ 60/30/150 mg |
4 months 5 times per week Continuation phase: RH 60/30 mg |
| 3–4 kg | ½ tablet | ½ tablet |
| 5–7 kg | 1 tablet | 1 tablet |
| 8–9 kg | 1 ½ tablets | 1 ½ tablets |
| 10–14 kg | 2 tablets | 2 tablets |
| 15–19 kg | 3 tablets | 3 tablets |
| 20–24 kg | 4 tablets | 4 tablets |
| 25–29 kg | 5 tablets | 5 tablets |
| 30–35 kg | 6 tablets | 6 tablets |
All 3 antituberculous drugs (RMP, INH and PZA) may cause a drug induced hepatitis. INH may cause a peripheral neuropathy, but this is very uncommon in children.